In 1982, graduated in Periodontology at Boston University., from the same University he obtained a Master of Science degree in Periodontology for an experimental study which he conducted between 1982 and 1983.
In 1987, dr de Sanctis was appointed professor of Periodontology at the II University of Rome where he taught until 1989.
From 1989 to 1999 he has held various teaching positions at the University of Bologna.
From 2000 to 2014 he was professor of Periodontology at the University of Siena.
From 2015 he was nominated Professor at the University Vita-Salute San Raffaele Milano
He is chair of the program of Periodontology
Director of the Clinical Department of Periodontology
He is Fellow of the International College of Dentistry,
Member of the American Academy of Periodontology
Past President of the Italian Society of Periodontology.
Past president of the Italian Coordinating Committee for the Scientific Societies