Dr. Nicola M Grande received his degree in Dentistry (DDS) from the Catholic University of Sacred Heart (UCSC), Rome, Italy in 1999 with a degree thesis on the fracture of NiTi rotary instruments. After two years in the Department of Endodontics at the same University, he served as an Assistant Professor in Endodontics from 2001 to 2009. He has been Professor of Endodontics in the School of Dental Hygiene (2002-2008). Since 2009 he is working as researcher in the Department of Endodontics at the University of Roma La Sapienza. He completed his PhD program at the Catholic University of Sacred Heart, in 2009, with a thesis on an innovative technique for the restoration of the endodontically treated teeth, that he has invented. Presently he is Professor of Endodontics II° at UCSC. His main scientific interests are the preparation of root canals with Nickel-Titanium rotary instruments, the study of anatomy and preparation of endodontic anatomy by micro-computed tomography techniques and the restoration of the endodontically treated teeth with new conservative approach. He contributed in the development of different instrument systems and new techniques and is holder of different international patents in the field of dentistry. He is certified member of the European Society of Endodontology (ESE), of the American Association of Endodontics (AAE) and active member of the Italian Society of Conservative Dentistry (SIDOC) and of the Italian Academy of Endodontics (AIE). Dr. Grande has published extensively in international peer-reviewed journals and lectures both nationally and internationally, he is working as specialist in endodontics and micro-surgery his own private clinic in Rome Italy.